Treg

Donor Regulatory T cells (Treg) infusion (DTI) in patients with steroid-refractory chronic graft-versus-host disease (cGVHD)

Treatment

• Experimental arm: infusion of T reg cells after rapamycin treatment
• Controle arm: rapamycin treatment only

Inclusion criteria:

• 18 years or older
• Grafts from HLA-identical siblings or HLA-matched unrelated donor (1 of 10 HLA-mismatch is allowed)
• Steroid-refractory or steroid-resistant chronic GVHD
• No prior failure of rapamycine as treatment for chronic GVHD
• Karnofsky performance score ≥ 70%

Exclusion criteria

• Fungal infection with radiological progression after treatment with amphotericine B or active azoles for > 1 month

Participating sites

• Centre Hospitalier Universitaire de Liège